In addition to kinetic tremor, patients may present several types of tremor, gait ataxia, hearing deficits and eye movement abnormalities.
Non-motor symptoms and signs have also added to definition of ET. There is significant evidence indicating the neurodegenerative nature of the disease. New studies indicate that inflammation may have a place in the etiology.
Temporary brain perfusion disturbances transient ischemic attacks, TIAs The blood platelet thrombocyte count plays a significant role in blood coagulation. Both the number of platelets and their function are responsible for the balance of the coagulation system.
The neutrophil-to lymphocyte ratio NLR and the platelet-to lymphocyte ratio PLR have recently begun to be used as a marker of systemic inflammation.
Our study aims at finding a clue for systemic inflammation in ET. Methods - 67 patients with ET and 40 healthy controls were recruited for the study.
The total white blood cells WBCabsolute neutrophil count, lymphocyte count and platelet count were retrieved. The NLR was calculated by dividing the neutrophil count by the lymphocyte count and the PLR was calculated by dividing the platelet count by the lymphocyte count.
Results - Patient and control groups were similar in terms of age and gender.
The mean age of patient group was The NLRs were 1. For hypertension headache signs patient group and the control group the PLRs were Conclusion - The pathophysiological mechanism for essential tremor ET remains unclear. However, there is an increasing amount of research being conducted on the subject. Although previous studies showed that neuroinflammation could be a part of etiology of disease, this study has failed to demonstrate systemic inflammation in ET.